6U6B

Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site

Summary for 6U6B

• Entry DOI: 10.2210/pdb6u6b/pdb
• Related: 6U2O
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: polymerase, cisplatin, mismatch, pt-gg, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48653.97

Authors

Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S. (deposition date: 2019-08-29, release date: 2020-09-09, Last modification date: 2023-10-11)

• Primary citation: Ouzon-Shubeita, H.,Vilas, C.K.,Lee, S.; Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion.; Biochem.J., 477:937-951, 2020; PubMed: 32039434; DOI: 10.1042/BCJ20190906

Experimental method

X-RAY DIFFRACTION (3.108 Å)