6U2F

PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2

Summary for 6U2F

• Entry DOI: 10.2210/pdb6u2f/pdb
• Related PRD ID: PRD_002363
• Descriptor: Proprotein convertase subtilisin/kexin type 9, Organo-peptide PCSK9 inhibitor, 7G7 heavy chain, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase-hydrolase inhibitor-immune system complex, hydrolase/hydrolase inhibitor/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 124811.30

Authors

Ultsch, M.H.,Kirchhofer, D. (deposition date: 2019-08-19, release date: 2020-02-05, Last modification date: 2023-11-15)

• Primary citation: Burdick, D.J.,Skelton, N.J.,Ultsch, M.,Beresini, M.H.,Eigenbrot, C.,Li, W.,Zhang, Y.,Nguyen, H.,Kong-Beltran, M.,Quinn, J.G.,Kirchhofer, D.; Design of Organo-Peptides As Bipartite PCSK9 Antagonists.; Acs Chem.Biol., 15:425-436, 2020; PubMed: 31962046; DOI: 10.1021/acschembio.9b00899

Experimental method

X-RAY DIFFRACTION (2.94 Å)