6U22

Crystal structure of SFTI-triazole inhibitor in complex with beta-trypsin

Summary for 6U22

Entry DOI	10.2210/pdb6u22/pdb
Descriptor	Cationic trypsin, GLY-ARG-ALA-THR-LYS-SER-ILE-PRO-PRO-ILE-ALA-PHE-PRO-ASP, CALCIUM ION, ... (5 entities in total)
Functional Keywords	triazole, peptidomimetic, biosynthetic protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	2
Total formula weight	24919.16
Authors	White, A.M.,King, G.J.,Durek, T.,Craik, D.J. (deposition date: 2019-08-19, release date: 2020-07-01, Last modification date: 2023-10-11)
Primary citation	White, A.M.,de Veer, S.J.,Wu, G.,Harvey, P.J.,Yap, K.,King, G.J.,Swedberg, J.E.,Wang, C.K.,Law, R.H.P.,Durek, T.,Craik, D.J. Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angew.Chem.Int.Ed.Engl., 59:11273-11277, 2020 Cited by PubMed: 32270580 DOI: 10.1002/anie.202003435 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation