6TZH

ADC-7 in complex with boronic acid transition state inhibitor S06015

Summary for 6TZH

• Entry DOI: 10.2210/pdb6tzh/pdb
• Descriptor: Beta-lactamase, phosphonooxy-[(4-thiophen-3-yl-1,2,3-triazol-1-yl)methyl]borinic acid, GLYCINE, ... (5 entities in total)
• Functional Keywords: inhibitor, beta-lactamase, batsi, adc-7, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 4
• Total formula weight: 164860.34

Authors

Fish, E.R.,Powers, R.A.,Wallar, B.J. (deposition date: 2019-08-12, release date: 2020-06-24, Last modification date: 2020-07-22)

• Primary citation: Caselli, E.,Fini, F.,Introvigne, M.L.,Stucchi, M.,Taracila, M.A.,Fish, E.R.,Smolen, K.A.,Rather, P.N.,Powers, R.A.,Wallar, B.J.,Bonomo, R.A.,Prati, F.; 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors againstAcinetobacter baumanniiCephalosporinase.; Acs Infect Dis., 6:1965-1975, 2020; PubMed: 32502340; DOI: 10.1021/acsinfecdis.0c00254

Experimental method

X-RAY DIFFRACTION (2.04 Å)