6TZH
ADC-7 in complex with boronic acid transition state inhibitor S06015
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue ERF A 401 |
| Chain | Residue |
| A | GLY63 |
| A | ARG340 |
| A | GLY402 |
| A | HOH506 |
| A | HOH543 |
| A | SER64 |
| A | GLN120 |
| A | TYR150 |
| A | ASN152 |
| A | LYS312 |
| A | THR313 |
| A | GLY314 |
| A | SER315 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GLY A 402 |
| Chain | Residue |
| A | TYR222 |
| A | THR316 |
| A | SER317 |
| A | ERF401 |
| A | HOH517 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | ARG340 |
| B | ILE341 |
| B | PRO342 |
| B | HOH534 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GLY B 403 |
| Chain | Residue |
| B | TYR222 |
| B | THR316 |
| B | SER317 |
| B | ERF401 |
| B | HOH556 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GLY B 404 |
| Chain | Residue |
| B | LEU119 |
| B | VAL292 |
| B | MET293 |
| B | ARG340 |
| B | ERF401 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GLY C 402 |
| Chain | Residue |
| C | TYR222 |
| C | SER317 |
| C | ERF401 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GLY D 402 |
| Chain | Residue |
| D | VAL212 |
| D | TYR222 |
| D | SER315 |
| D | THR316 |
| D | SER317 |
| D | ERF401 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide ERF B 401 and SER B 64 |
| Chain | Residue |
| B | LEU62 |
| B | GLY63 |
| B | VAL65 |
| B | SER66 |
| B | LYS67 |
| B | GLN120 |
| B | TYR150 |
| B | ASN152 |
| B | LYS312 |
| B | THR313 |
| B | GLY314 |
| B | SER315 |
| B | THR316 |
| B | ARG340 |
| B | GLY403 |
| B | GLY404 |
| B | HOH513 |
| B | HOH583 |
| B | HOH589 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ERF C 401 and SER C 64 |
| Chain | Residue |
| C | LEU62 |
| C | GLY63 |
| C | VAL65 |
| C | SER66 |
| C | LYS67 |
| C | GLN120 |
| C | TYR150 |
| C | ASN152 |
| C | LYS312 |
| C | THR313 |
| C | GLY314 |
| C | SER315 |
| C | GLY402 |
| C | HOH506 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ERF D 401 and SER D 64 |
| Chain | Residue |
| D | LEU62 |
| D | GLY63 |
| D | VAL65 |
| D | SER66 |
| D | LYS67 |
| D | GLN120 |
| D | TYR150 |
| D | ASN152 |
| D | LYS312 |
| D | THR313 |
| D | GLY314 |
| D | SER315 |
| D | THR316 |
| D | ARG340 |
| D | GLY402 |
| D | HOH504 |
Functional Information from PROSITE/UniProt
| site_id | PS00336 |
| Number of Residues | 8 |
| Details | BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSVSK |
| Chain | Residue | Details |
| A | PHE60-LYS67 |
