6TY6
Variant W229D/F290W-2 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4) bound to 5(6)-nitrobenzotriazole (TS-analog)
Summary for 6TY6
| Entry DOI | 10.2210/pdb6ty6/pdb |
| Related | 5FQI 5FQK |
| Descriptor | Beta lactamase (GNCA4-2), GLYCEROL, FORMIC ACID, ... (7 entities in total) |
| Functional Keywords | hydrolase, antibiotic resistance, ancestral reconstructed |
| Biological source | synthetic construct |
| Total number of polymer chains | 3 |
| Total formula weight | 88992.48 |
| Authors | Gavira, J.A.,Risso, V.,Sanchez-Ruiz, J.M.,Romero-Rivera, A.,Kamerlin, S.C.L.,Ortega-Munoz, M.,Santoyo-Gonzalez, F. (deposition date: 2020-01-15, release date: 2020-06-03, Last modification date: 2024-01-24) |
| Primary citation | Risso, V.A.,Romero-Rivera, A.,Gutierrez-Rus, L.I.,Ortega-Munoz, M.,Santoyo-Gonzalez, F.,Gavira, J.A.,Sanchez-Ruiz, J.M.,Kamerlin, S.C.L. Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Chem Sci, 11:6134-6148, 2020 Cited by PubMed: 32832059DOI: 10.1039/d0sc01935f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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