6TY5
Crystal structure of human TLR8 in complex with Compound 11
6TY5 の概要
エントリーDOI | 10.2210/pdb6ty5/pdb |
分子名称 | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
機能のキーワード | rna recognition leucine rich repeats glycosylation structure based drug design immune system innate immunity, immune system |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 192811.25 |
構造登録者 | |
主引用文献 | Knoepfel, T.,Nimsgern, P.,Jacquier, S.,Bourrel, M.,Vangrevelinghe, E.,Glatthar, R.,Behnke, D.,Alper, P.B.,Michellys, P.Y.,Deane, J.,Junt, T.,Zipfel, G.,Limonta, S.,Hawtin, S.,Andre, C.,Boulay, T.,Loetscher, P.,Faller, M.,Blank, J.,Feifel, R.,Betschart, C. Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay. J.Med.Chem., 63:8276-8295, 2020 Cited by PubMed: 32786235DOI: 10.1021/acs.jmedchem.0c00130 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.793 Å) |
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