6TXB

Crystal structure of Mindy1 mutant (P138A) in complex with Lys48 linked di-ubiquitin

Summary for 6TXB

Entry DOI	10.2210/pdb6txb/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase MINDY-1, Polyubiquitin-C, SODIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, cysteine protease, isopeptidase and ubiquitin binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	57873.47
Authors	Abdul Rehman, S.A.,Kulathu, Y. (deposition date: 2020-01-14, release date: 2021-01-27, Last modification date: 2024-01-24)
Primary citation	Abdul Rehman, S.A.,Armstrong, L.A.,Lange, S.M.,Kristariyanto, Y.A.,Grawert, T.W.,Knebel, A.,Svergun, D.I.,Kulathu, Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell, 81:4176-4190.e6, 2021 Cited by PubMed: 34529927 DOI: 10.1016/j.molcel.2021.08.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation