6TW4
HumRadA22F in complex with compound 6
Summary for 6TW4
Entry DOI | 10.2210/pdb6tw4/pdb |
Descriptor | DNA repair and recombination protein RadA, ~{N}-[2-[(2~{S})-2-[[(1~{S})-1-(4-methoxyphenyl)ethyl]carbamoyl]pyrrolidin-1-yl]-2-oxidanylidene-ethyl]quinoline-2-carboxamide, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | rad51, recombinase, dna repair, dna binding protein |
Biological source | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
Total number of polymer chains | 1 |
Total formula weight | 27214.96 |
Authors | Marsh, M.E.,Scott, D.E.,Coyne, A.G.,Skidmore, J.,Abell, C.,Hyvonen, M. (deposition date: 2020-01-12, release date: 2021-01-27, Last modification date: 2024-01-24) |
Primary citation | Scott, D.E.,Francis-Newton, N.J.,Marsh, M.E.,Coyne, A.G.,Fischer, G.,Moschetti, T.,Bayly, A.R.,Sharpe, T.D.,Haas, K.T.,Barber, L.,Valenzano, C.R.,Srinivasan, R.,Huggins, D.J.,Lee, M.,Emery, A.,Hardwick, B.,Ehebauer, M.,Dagostin, C.,Esposito, A.,Pellegrini, L.,Perrior, T.,McKenzie, G.,Blundell, T.L.,Hyvonen, M.,Skidmore, J.,Venkitaraman, A.R.,Abell, C. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol, 28:835-, 2021 Cited by PubMed: 33662256DOI: 10.1016/j.chembiol.2021.02.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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