6TUL

Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021177

This is a non-PDB format compatible entry.

Summary for 6TUL

• Entry DOI: 10.2210/pdb6tul/pdb
• Related: 6SRV 6SRX 6SS0 6SS2 6SS4 6SS5 6SS6
• Descriptor: Fab C0021177 heavy chain (IgG1), Fab C0021177 light chain (IgG1), TETRAETHYLENE GLYCOL, ... (7 entities in total)
• Functional Keywords: arginase-2 inhibitor, igg, antigen-binding fragment, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 48941.50

Authors

Burschowsky, D.,Addyman, A.,Fiedler, S.,Groves, M.,Haynes, S.,Seewooruthun, C.,Carr, M. (deposition date: 2020-01-07, release date: 2020-06-10, Last modification date: 2024-01-24)

• Primary citation: Austin, M.,Burschowsky, D.,Chan, D.T.Y.,Jenkinson, L.,Haynes, S.,Diamandakis, A.,Seewooruthun, C.,Addyman, A.,Fiedler, S.,Ryman, S.,Whitehouse, J.,Slater, L.H.,Hadjinicolaou, A.V.,Gileadi, U.,Gowans, E.,Shibata, Y.,Barnard, M.,Kaserer, T.,Sharma, P.,Luheshi, N.M.,Wilkinson, R.W.,Vaughan, T.J.,Holt, S.V.,Cerundolo, V.,Carr, M.D.,Groves, M.A.T.; Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.; Mabs, 12:1801230-1801230, ; PubMed: 32880207; DOI: 10.1080/19420862.2020.1801230

Experimental method

X-RAY DIFFRACTION (2.25 Å)