6TUG

Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP

Summary for 6TUG

Entry DOI	10.2210/pdb6tug/pdb
Descriptor	CRISPR system endoribonuclease Csm6, 2'-deoxy-2'-fluoroadenosine 5'-(dihydrogen phosphate), SULFATE ION, ... (4 entities in total)
Functional Keywords	crispr, cyclic oligoadenylate, rnase, nuclease, rna binding protein
Biological source	Enterococcus italicus (strain DSM 15952 / LMG 22039 / TP 1.5)
Total number of polymer chains	8
Total formula weight	416501.47
Authors	Garcia-Doval, C.,Jinek, M. (deposition date: 2020-01-07, release date: 2020-02-26, Last modification date: 2024-05-15)
Primary citation	Garcia-Doval, C.,Schwede, F.,Berk, C.,Rostol, J.T.,Niewoehner, O.,Tejero, O.,Hall, J.,Marraffini, L.A.,Jinek, M. Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6. Nat Commun, 11:1596-1596, 2020 Cited by PubMed: 32221291 DOI: 10.1038/s41467-020-15334-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation