6TUC

Human Aldose Reductase in complex with ALR25

Summary for 6TUC

• Entry DOI: 10.2210/pdb6tuc/pdb
• Related: 4QBX 4YS1 6SYW
• Descriptor: aldose reductase, CITRIC ACID, 2-(2-((3-boronobenzyl)carbamoyl)-5-fluorophenoxy)acetic acid, ... (5 entities in total)
• Functional Keywords: diabetes, oxidoreductase, transient binding pocket, diabetic late effects, polyol pathway, osmotic and oxidative stress, cofactor, nadph, nadp+, akr1b1, aldr1, alr2
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37180.97

Authors

Sandner, A.,Heine, A.,Klebe, G. (deposition date: 2020-01-06, release date: 2021-01-27, Last modification date: 2024-01-24)

• Primary citation: Sandner, A.,Heine, A.,Klebe, G.,Ngo, K.; Human Aldose Reductase in complex with SAR25; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.06 Å)