6TU9

The ROR1 Pseudokinase Domain Bound To Ponatinib

Summary for 6TU9

• Entry DOI: 10.2210/pdb6tu9/pdb
• Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total)
• Functional Keywords: receptor transmembrane kinase pseudokinase small-molecule inhibitor, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71962.55

Authors

Mathea, S.,Preuss, F.,Chatterjee, D.,Niininen, W.,Ungureanu, D.,Shin, D.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (deposition date: 2020-01-04, release date: 2020-01-22, Last modification date: 2024-01-24)

• Primary citation: Sheetz, J.B.,Mathea, S.,Karvonen, H.,Malhotra, K.,Chatterjee, D.,Niininen, W.,Perttila, R.,Preuss, F.,Suresh, K.,Stayrook, S.E.,Tsutsui, Y.,Radhakrishnan, R.,Ungureanu, D.,Knapp, S.,Lemmon, M.A.; Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.; Mol.Cell, 79:390-405.e7, 2020; PubMed: 32619402; DOI: 10.1016/j.molcel.2020.06.018

Experimental method

X-RAY DIFFRACTION (1.94 Å)