6TU9

The ROR1 Pseudokinase Domain Bound To Ponatinib

6TU9 の概要

• エントリーDOI: 10.2210/pdb6tu9/pdb
• 分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total)
• 機能のキーワード: receptor transmembrane kinase pseudokinase small-molecule inhibitor, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71962.55

構造登録者

Mathea, S.,Preuss, F.,Chatterjee, D.,Niininen, W.,Ungureanu, D.,Shin, D.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (登録日: 2020-01-04, 公開日: 2020-01-22, 最終更新日: 2024-01-24)

• 主引用文献: Sheetz, J.B.,Mathea, S.,Karvonen, H.,Malhotra, K.,Chatterjee, D.,Niininen, W.,Perttila, R.,Preuss, F.,Suresh, K.,Stayrook, S.E.,Tsutsui, Y.,Radhakrishnan, R.,Ungureanu, D.,Knapp, S.,Lemmon, M.A.; Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.; Mol.Cell, 79:390-405.e7, 2020; PubMed: 32619402; DOI: 10.1016/j.molcel.2020.06.018

実験手法

X-RAY DIFFRACTION (1.94 Å)