6TTG

Crystal structure of the ATP binding domain of S. aureus GyrB complexed with LMD62

Summary for 6TTG

• Entry DOI: 10.2210/pdb6ttg/pdb
• Descriptor: DNA gyrase subunit B, 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-(2-morpholin-4-ylethoxy)-1,3-benzothiazole-6-carboxylic acid, GLYCEROL, ... (8 entities in total)
• Functional Keywords: dna gyrase, gyrb, isomerase
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 2
• Total formula weight: 49724.97

Authors

Welin, M.,Kimbung, R.,Focht, D. (deposition date: 2019-12-27, release date: 2020-12-30, Last modification date: 2024-01-24)

• Primary citation: Durcik, M.,Nyerges, A.,Skok, Z.,Skledar, D.G.,Trontelj, J.,Zidar, N.,Ilas, J.,Zega, A.,Cruz, C.D.,Tammela, P.,Welin, M.,Kimbung, Y.R.,Focht, D.,Benek, O.,Revesz, T.,Draskovits, G.,Szili, P.E.,Daruka, L.,Pal, C.,Kikelj, D.,Masic, L.P.,Tomasic, T.; New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.; Eur.J.Med.Chem., 213:113200-113200, 2021; PubMed: 33524686; DOI: 10.1016/j.ejmech.2021.113200

Experimental method

X-RAY DIFFRACTION (1.7 Å)