6TT2
The PH domain of Bruton's tyrosine kinase mutant R28C
Summary for 6TT2
Entry DOI | 10.2210/pdb6tt2/pdb |
Descriptor | Tyrosine-protein kinase BTK, MAGNESIUM ION, ZINC ION, ... (4 entities in total) |
Functional Keywords | btk, covalent fragments, surface entrophy reduction, crystal engineering, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40037.35 |
Authors | Brear, P.,Wagstaff, J.,Hyvonen, M. (deposition date: 2019-12-23, release date: 2020-11-25, Last modification date: 2024-01-24) |
Primary citation | Brear, P.,Fischer, G.,May, M.,Pantelejevs, T.,Mathieu, R.,Rossmann, M.,Wagstaff, J.,Blaszczyk, B.,Hyvonen, M. Crystal Structure of 1-methylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
Download full validation report