6TRY

Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with MF13 inhibitor compound

Summary for 6TRY

• Entry DOI: 10.2210/pdb6try/pdb
• Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 8-(4-chlorophenyl)-2-phenyl-imidazo[1,2-a]pyridine, ... (5 entities in total)
• Functional Keywords: dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 114383.07

Authors

Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2019-12-19, release date: 2021-01-13, Last modification date: 2024-01-24)

• Primary citation: Quattrini, L.,Gelardi, E.L.M.,Petrarolo, G.,Colombo, G.,Ferraris, D.M.,Picarazzi, F.,Rizzi, M.,Garavaglia, S.,La Motta, C.; Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2- a ]pyridines against the 1A Family.; Acs Med.Chem.Lett., 11:963-970, 2020; PubMed: 32435412; DOI: 10.1021/acsmedchemlett.9b00686

Experimental method

X-RAY DIFFRACTION (2.9 Å)