6TPA

CDK8/CyclinC in complex with drug ETP-50775

Summary for 6TPA

• Entry DOI: 10.2210/pdb6tpa/pdb
• Descriptor: Cyclin-dependent kinase 8, Cyclin-C, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, ... (6 entities in total)
• Functional Keywords: cell division kinase inhibitor, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 81881.39

Authors

Munoz, I.G.,Pastor, J.,Martinez, S. (deposition date: 2019-12-12, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Martinez-Gonzalez, S.,Garcia, A.B.,Albarran, M.I.,Cebria, A.,Amezquita-Alves, A.,Garcia-Campos, F.J.,Martinez-Gago, J.,Martinez-Torrecuadrada, J.,Munoz, I.,Blanco-Aparicio, C.,Pastor, J.; Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors.; Eur.J.Med.Chem., 201:112443-112443, 2020; PubMed: 32599324; DOI: 10.1016/j.ejmech.2020.112443

Experimental method

X-RAY DIFFRACTION (2.8 Å)