6TLT

ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand Glenmark

Summary for 6TLT

• Entry DOI: 10.2210/pdb6tlt/pdb
• Descriptor: Nuclear receptor ROR-gamma, 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, desmosterol, ... (5 entities in total)
• Functional Keywords: nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 31422.19

Authors

de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2019-12-03, release date: 2020-12-16, Last modification date: 2024-01-24)

• Primary citation: de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L.; Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33536342; DOI: 10.1073/pnas.2021287118

Experimental method

X-RAY DIFFRACTION (2.11 Å)