6TLT
ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand Glenmark
Summary for 6TLT
Entry DOI | 10.2210/pdb6tlt/pdb |
Descriptor | Nuclear receptor ROR-gamma, 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, desmosterol, ... (5 entities in total) |
Functional Keywords | nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31422.19 |
Authors | de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2019-12-03, release date: 2020-12-16, Last modification date: 2024-01-24) |
Primary citation | de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L. Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33536342DOI: 10.1073/pnas.2021287118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
Download full validation report