6TLK

Structure of methylene-tetrahydromethanopterin dehydrogenase from Methylorubrum extorquens AM1 in an open conformation containing NADP+ and methylene-H4MPT

Summary for 6TLK

• Entry DOI: 10.2210/pdb6tlk/pdb
• Descriptor: Bifunctional protein MdtA, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FORMIC ACID, ... (8 entities in total)
• Functional Keywords: one-carbon metabolism; enzyme catalysis; dehydrogenase; conformational changes; methylotrophy, oxidoreductase
• Biological source: Methylorubrum extorquens AM1
• Total number of polymer chains: 6
• Total formula weight: 196324.87

Authors

Wagner, T.,Huang, G.,Demmer, U.,Warkentin, E.,Ermler, U.,Shima, S. (deposition date: 2019-12-02, release date: 2020-02-26, Last modification date: 2024-01-24)

• Primary citation: Huang, G.,Wagner, T.,Demmer, U.,Warkentin, E.,Ermler, U.,Shima, S.; The Hydride Transfer Process in NADP-dependent Methylene-tetrahydromethanopterin Dehydrogenase.; J.Mol.Biol., 432:2042-2054, 2020; PubMed: 32061937; DOI: 10.1016/j.jmb.2020.01.042

Experimental method

X-RAY DIFFRACTION (1.8 Å)