6TLC
Unphosphorylated human STAT3 in complex with MS3-6 monobody
Summary for 6TLC
Entry DOI | 10.2210/pdb6tlc/pdb |
Descriptor | Signal transducer and activator of transcription 3, Monobody (3 entities in total) |
Functional Keywords | inhibitor, complex, stat3, monobody, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 156752.86 |
Authors | La Sala, G.,Lau, K.,Reynaud, A.,Pojer, F.,Hantschel, O. (deposition date: 2019-12-02, release date: 2020-07-22, Last modification date: 2024-01-24) |
Primary citation | La Sala, G.,Michiels, C.,Kukenshoner, T.,Brandstoetter, T.,Maurer, B.,Koide, A.,Lau, K.,Pojer, F.,Koide, S.,Sexl, V.,Dumoutier, L.,Hantschel, O. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat Commun, 11:4115-4115, 2020 Cited by PubMed: 32807795DOI: 10.1038/s41467-020-17920-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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