6TJN
Human transthyretin (TTR) complexed with (E)-3-(((4-hydroxybenzylidene)amino)oxy)propanoic acid
Summary for 6TJN
Entry DOI | 10.2210/pdb6tjn/pdb |
Descriptor | Transthyretin, 3-[(~{E})-(4-hydroxyphenyl)methylideneamino]oxypropanoic acid (3 entities in total) |
Functional Keywords | transthyretin, ttr, inhibitor, complex, protein transport |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 28087.22 |
Authors | Ciccone, L.,Shepard, W.,Nencetti, S.,Orlandini, E.,Rossello, A. (deposition date: 2019-11-26, release date: 2020-12-16, Last modification date: 2024-01-24) |
Primary citation | Ciccone, L.,Nencetti, S.,Tonali, N.,Fruchart-Gaillard, C.,Shepard, W.,Nuti, E.,Camodeca, C.,Rossello, A.,Orlandini, E. Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis. Bioorg.Med.Chem., 28:115673-115673, 2020 Cited by PubMed: 32828431DOI: 10.1016/j.bmc.2020.115673 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.702 Å) |
Structure validation
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