6TJN

Human transthyretin (TTR) complexed with (E)-3-(((4-hydroxybenzylidene)amino)oxy)propanoic acid

Summary for 6TJN

Entry DOI	10.2210/pdb6tjn/pdb
Descriptor	Transthyretin, 3-[(~{E})-(4-hydroxyphenyl)methylideneamino]oxypropanoic acid (3 entities in total)
Functional Keywords	transthyretin, ttr, inhibitor, complex, protein transport
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	28087.22
Authors	Ciccone, L.,Shepard, W.,Nencetti, S.,Orlandini, E.,Rossello, A. (deposition date: 2019-11-26, release date: 2020-12-16, Last modification date: 2024-01-24)
Primary citation	Ciccone, L.,Nencetti, S.,Tonali, N.,Fruchart-Gaillard, C.,Shepard, W.,Nuti, E.,Camodeca, C.,Rossello, A.,Orlandini, E. Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis. Bioorg.Med.Chem., 28:115673-115673, 2020 Cited by PubMed: 32828431 DOI: 10.1016/j.bmc.2020.115673 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.702 Å)

Structure validation