6TIW
Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)
Summary for 6TIW
Entry DOI | 10.2210/pdb6tiw/pdb |
EMDB information | 10421 |
Descriptor | Kinesin-like protein KIF11, Tubulin beta chain, Tubulin alpha-1B chain, ... (6 entities in total) |
Functional Keywords | kinesin, microtubule, mitosis, inhibition, motor, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 142003.00 |
Authors | Pena, A.,Sweeney, A.,Cook, A.D.,Moores, C.A.,Topf, M. (deposition date: 2019-11-22, release date: 2020-03-04, Last modification date: 2024-05-15) |
Primary citation | Pena, A.,Sweeney, A.,Cook, A.D.,Topf, M.,Moores, C.A. Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28:450-457.e5, 2020 Cited by PubMed: 32084356DOI: 10.1016/j.str.2020.01.013 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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