6TI7

Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils

Summary for 6TI7

• Entry DOI: 10.2210/pdb6ti7/pdb
• Related: 6TI6
• NMR Information: BMRB: 34456
• Descriptor: Amyloid-beta precursor protein (2 entities in total)
• Functional Keywords: amyloid beta peptides alzheimer's disease solid-state nmr supramolecular assembly, protein fibril
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 70847.51

Authors

Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, A.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C. (deposition date: 2019-11-21, release date: 2020-07-22, Last modification date: 2024-06-19)

• Primary citation: Cerofolini, L.,Ravera, E.,Bologna, S.,Wiglenda, T.,Boddrich, A.,Purfurst, B.,Benilova, I.,Korsak, M.,Gallo, G.,Rizzo, D.,Gonnelli, L.,Fragai, M.,De Strooper, B.,Wanker, E.E.,Luchinat, C.; Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.; Chem.Commun.(Camb.), 56:8830-8833, 2020; PubMed: 32749391; DOI: 10.1039/d0cc02463e

Experimental method

SOLID-STATE NMR