6TFV
Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18b
Summary for 6TFV
Entry DOI | 10.2210/pdb6tfv/pdb |
Descriptor | Epidermal growth factor receptor, ~{N}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | her2, egfr, covalent inhibitors, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77651.76 |
Authors | Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2019-11-14, release date: 2020-09-30, Last modification date: 2024-01-24) |
Primary citation | Lategahn, J.,Hardick, J.,Grabe, T.,Niggenaber, J.,Jeyakumar, K.,Keul, M.,Tumbrink, H.L.,Becker, C.,Hodson, L.,Kirschner, T.,Klovekorn, P.,Ketzer, J.,Baumann, M.,Terheyden, S.,Unger, A.,Weisner, J.,Muller, M.P.,van Otterlo, W.A.L.,Bauer, S.,Rauh, D. Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach. J.Med.Chem., 63:11725-11755, 2020 Cited by PubMed: 32931277DOI: 10.1021/acs.jmedchem.0c00870 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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