6TF6

Human galectin-3c in complex with a galactose derivative

Summary for 6TF6

• Entry DOI: 10.2210/pdb6tf6/pdb
• Descriptor: Galectin-3, CHLORIDE ION, ~{N}-[[(2~{S},3~{S},4~{R},5~{S},6~{R})-4-[[5,6-bis(fluoranyl)-2-oxidanylidene-chromen-3-yl]methoxy]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]methyl]-4-fluoranyl-naphthalene-1-carboxamide, ... (4 entities in total)
• Functional Keywords: sugar binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16365.52

Authors

Nilsson, U.J.,Zetterberg, F.,Hakansson, M.,Logan, D.T. (deposition date: 2019-11-13, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Dahlqvist, A.,Mandal, S.,Peterson, K.,Hakansson, M.,Logan, D.T.,Zetterberg, F.R.,Leffler, H.,Nilsson, U.J.; 3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.; Molecules, 24:-, 2019; PubMed: 31842451; DOI: 10.3390/molecules24244554

Experimental method

X-RAY DIFFRACTION (1.5 Å)