6TEV
The structure of CYP121 in complex with inhibitor L44
Summary for 6TEV
| Entry DOI | 10.2210/pdb6tev/pdb |
| Descriptor | Mycocyclosin synthase, 1-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]imidazole, 1,2-ETHANEDIOL, ... (5 entities in total) |
| Functional Keywords | cyp121, inhibitor, complex, oxidoreductase |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 1 |
| Total formula weight | 44651.07 |
| Authors | Adam, S.,Koehnke, J. (deposition date: 2019-11-12, release date: 2021-05-26, Last modification date: 2024-01-24) |
| Primary citation | Walter, I.,Adam, S.,Gentilini, M.V.,Kany, A.M.,Brengel, C.,Thomann, A.,Sparwasser, T.,Kohnke, J.,Hartmann, R.W. Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors. Chemmedchem, 16:2786-2801, 2021 Cited by PubMed: 34010508DOI: 10.1002/cmdc.202100283 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.70001263917 Å) |
Structure validation
Download full validation report
