6TE7
The structure of CYP121 in complex with inhibitor S2
Summary for 6TE7
Entry DOI | 10.2210/pdb6te7/pdb |
Descriptor | Mycocyclosin synthase, 2-chloranyl-4-[4-[(1~{R})-1-imidazol-1-ylprop-2-enyl]phenyl]phenol, TRIETHYLENE GLYCOL, ... (6 entities in total) |
Functional Keywords | cyp121, complex, inhibitor, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 44445.37 |
Authors | Adam, S.,Koehnke, J. (deposition date: 2019-11-11, release date: 2021-05-26, Last modification date: 2024-01-24) |
Primary citation | Walter, I.,Adam, S.,Gentilini, M.V.,Kany, A.M.,Brengel, C.,Thomann, A.,Sparwasser, T.,Kohnke, J.,Hartmann, R.W. Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors. Chemmedchem, 16:2786-2801, 2021 Cited by PubMed: 34010508DOI: 10.1002/cmdc.202100283 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.50001818022 Å) |
Structure validation
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