6TE5
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with LQ43 inhibitor compound
Summary for 6TE5
Entry DOI | 10.2210/pdb6te5/pdb |
Related | 6S6W |
Descriptor | Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine, ... (5 entities in total) |
Functional Keywords | dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 114494.33 |
Authors | Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2019-11-11, release date: 2020-11-18, Last modification date: 2024-01-24) |
Primary citation | Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C. Imidazo[1,2- a ]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells. J.Med.Chem., 63:4603-4616, 2020 Cited by PubMed: 32223240DOI: 10.1021/acs.jmedchem.9b01910 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
Download full validation report