6S6W

Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+

Summary for 6S6W

Entry DOI	10.2210/pdb6s6w/pdb
Descriptor	Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (5 entities in total)
Functional Keywords	aldh1a3 ga11 glioma 2, 6-diphenylimidazo[1, 2-a]pyridine retinaldehyde dehydrogenase inhinitor aldhs, cytosolic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	109408.77
Authors	Gelardi, E.L.M.,Quattrini, L.,LaMotta, C.,Ferraris, D.M.,Garavaglia, S. (deposition date: 2019-07-03, release date: 2020-04-22, Last modification date: 2024-01-24)
Primary citation	Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C. Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells. J.Med.Chem., 63:4603-4616, 2020 Cited by PubMed: 32223240 DOI: 10.1021/acs.jmedchem.9b01910 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation