6TE5

Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with LQ43 inhibitor compound

Summary for 6TE5

Entry DOI	10.2210/pdb6te5/pdb
Related	6S6W
Descriptor	Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine, ... (5 entities in total)
Functional Keywords	dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	114494.33
Authors	Gelardi, E.L.M.,Garavaglia, S. (deposition date: 2019-11-11, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C. Imidazo[1,2- a ]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells. J.Med.Chem., 63:4603-4616, 2020 Cited by PubMed: 32223240 DOI: 10.1021/acs.jmedchem.9b01910 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.25 Å)

Structure validation