6TE5

Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with LQ43 inhibitor compound

6TE5 の概要

• エントリーDOI: 10.2210/pdb6te5/pdb
• 関連するPDBエントリー: 6S6W
• 分子名称: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine, ... (5 entities in total)
• 機能のキーワード: dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114494.33

構造登録者

Gelardi, E.L.M.,Garavaglia, S. (登録日: 2019-11-11, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C.; Imidazo[1,2- a ]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.; J.Med.Chem., 63:4603-4616, 2020; PubMed: 32223240; DOI: 10.1021/acs.jmedchem.9b01910

実験手法