6TCR

Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant

6TCR の概要

• エントリーDOI: 10.2210/pdb6tcr/pdb
• 分子名称: Omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: fab, antibody, immunoglobulin, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49280.58

構造登録者

Mitropoulou, A.N.,Ceska, T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M. (登録日: 2019-11-06, 公開日: 2020-03-18, 最終更新日: 2024-01-24)

• 主引用文献: Mitropoulou, A.N.,Ceska, T.,Heads, J.T.,Beavil, A.J.,Henry, A.J.,McDonnell, J.M.,Sutton, B.J.,Davies, A.M.; Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.; Acta Crystallogr.,Sect.F, 76:116-129, 2020; PubMed: 32133997; DOI: 10.1107/S2053230X20001466

実験手法

X-RAY DIFFRACTION (1.45 Å)