6TBX

Trypanosoma brucei PTR1 (TbPTR1) in complex with a tricyclic-based inhibitor

6TBX の概要

• エントリーDOI: 10.2210/pdb6tbx/pdb
• 分子名称: Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol, ... (7 entities in total)
• 機能のキーワード: trypanosoma brucei, pteridine reductase, tbptr1, tricyclic based inhibitor, oxidoreductase
• 由来する生物種: Trypanosoma brucei brucei; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126739.81

構造登録者

Landi, G.,Tassone, G.,Pozzi, C.,Mangani, S. (登録日: 2019-11-04, 公開日: 2020-06-03, 最終更新日: 2024-01-24)

• 主引用文献: Landi, G.,Linciano, P.,Tassone, G.,Costi, M.P.,Mangani, S.,Pozzi, C.; High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor.; Acta Crystallogr D Struct Biol, 76:558-564, 2020; PubMed: 32496217; DOI: 10.1107/S2059798320004891

実験手法

X-RAY DIFFRACTION (1.3 Å)