6TAP

Structure of the dArc1 capsid

Summary for 6TAP

• Entry DOI: 10.2210/pdb6tap/pdb
• EMDB information: 10423
• Descriptor: Activity-regulated cytoskeleton associated protein 1, ZINC ION (2 entities in total)
• Functional Keywords: darc, gag, virus, vlp, virus like particle
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 5
• Total formula weight: 144671.41

Authors

Erlendsson, S.,Morado, D.R.,Shepherd, J.D.,Briggs, J.A.G. (deposition date: 2019-10-30, release date: 2020-01-01, Last modification date: 2024-07-10)

Primary citation

Erlendsson, S.,Morado, D.R.,Cullen, H.B.,Feschotte, C.,Shepherd, J.D.,Briggs, J.A.G.
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Nat.Neurosci., 23:172-175, 2020

PubMed Abstract: Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.

PubMed: 31907439
DOI: 10.1038/s41593-019-0569-y

Experimental method

ELECTRON MICROSCOPY (3.5 Å)