6T9Z

Nidocarborane inhibitor of Carbonic Anhydrase IX

Summary for 6T9Z

• Entry DOI: 10.2210/pdb6t9z/pdb
• Related: 6T7U
• Descriptor: Carbonic anhydrase 2, ZINC ION, Nidocarborane, ... (5 entities in total)
• Functional Keywords: carbonic anhydrase ix, ca inhibitor, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29587.92

Authors

Brynda, J.,Rezacova, P.,Kugler, M.,Gruner, B. (deposition date: 2019-10-29, release date: 2020-06-17, Last modification date: 2024-01-24)

• Primary citation: Dvoranova, J.,Kugler, M.,Holub, J.,Sicha, V.,Das, V.,Nekvinda, J.,El Anwar, S.,Havranek, M.,Pospisilova, K.,Fabry, M.,Kral, V.,Medvedikova, M.,Matejkova, S.,Liskova, B.,Gurska, S.,Dzubak, P.,Brynda, J.,Hajduch, M.,Gruner, B.,Rezacova, P.; Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.; Eur.J.Med.Chem., 200:112460-112460, 2020; PubMed: 32505851; DOI: 10.1016/j.ejmech.2020.112460

Experimental method

X-RAY DIFFRACTION (1.12 Å)