6T9R

Aplysia californica AChBP in complex with a cytisine derivative

This is a large structure.

Summary for 6T9R

DescriptorAcetylcholine binding protein, (1~{R},9~{S})-5-(3-oxidanylpropyl)-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, N-ACETYL-D-GLUCOSAMINE, ... (8 entities in total)
Functional Keywordsacetylcholine binding protein, nicotinic receptor surrogate, hydrolase
Biological sourceAplysia californica (California sea hare)
Total number of polymer chains10
Total molecular weight293433.86
Authors
Davis, S.,Hunter, W.N. (deposition date: 2019-10-28, release date: 2020-02-12, Last modification date: 2020-02-19)
Primary citation
Davis, S.,Rego Campello, H.,Gallagher, T.,Hunter, W.N.
The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica.
Acta Crystallogr.,Sect.F, 76:74-80, 2020
PubMed: 32039888 (PDB entries with the same primary citation)
DOI: 10.1107/S2053230X20001168
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.72 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20230 2.2% 1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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