6T8Q

HKATII IN COMPLEX WITH LIGAND (2R)-N-benzyl-1-[6-methyl-5-(oxan-4-yl)-7-oxo-6H,7H-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide

6T8Q の概要

• エントリーDOI: 10.2210/pdb6t8q/pdb
• 分子名称: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (2~{R})-1-[6-methyl-5-(oxan-4-yl)-7-oxidanylidene-[1,3]thiazolo[5,4-d]pyrimidin-2-yl]-~{N}-(phenylmethyl)pyrrolidine-2-carboxamide, CADMIUM ION, ... (6 entities in total)
• 機能のキーワード: alpha & beta protein, plp-dependent transferase, kat ii, kynurenine am, proteros biostructures gmbh, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52438.49

構造登録者

Blaesse, M.,Venalainen, J. (登録日: 2019-10-24, 公開日: 2020-03-04, 最終更新日: 2024-01-24)

• 主引用文献: Kalliokoski, T.,Rummakko, P.,Rantanen, M.,Blaesse, M.,Augustin, M.,Ummenthala, G.R.,Choudhary, S.,Venalainen, J.; Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors.; Bioorg.Med.Chem.Lett., 30:127060-127060, 2020; PubMed: 32113843; DOI: 10.1016/j.bmcl.2020.127060

実験手法

X-RAY DIFFRACTION (2.51 Å)