6T77

Crystal structure of Klebsiella pneumoniae FabG(NADPH-dependent) NADP-complex at 1.75 A resolution

Summary for 6T77

Entry DOI	10.2210/pdb6t77/pdb
Descriptor	3-oxoacyl-ACP reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywords	fatty acid biosynthesis, fabg, (3-oxoacyl-(acyl-carrier-protein) reductase), nadph, complex, fas-ii, biosynthetic protein
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	52733.29
Authors	Vella, P.,Schnell, R.,Lindqvist, Y.,Schneider, G. (deposition date: 2019-10-21, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Vella, P.,Rudraraju, R.S.,Lundback, T.,Axelsson, H.,Almqvist, H.,Vallin, M.,Schneider, G.,Schnell, R. A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens. Bioorg.Med.Chem., 30:115898-115898, 2021 Cited by PubMed: 33388594 DOI: 10.1016/j.bmc.2020.115898 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation