6T6R

Human endoplasmic reticulum aminopeptidase 1 (ERAP1) in complex with (4aR,5S,6R,8S,8aR)-5-(2-(Furan-3-yl)ethyl)-8-hydroxy-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid

6T6R の概要

• エントリーDOI: 10.2210/pdb6t6r/pdb
• 分子名称: Endoplasmic reticulum aminopeptidase 1, ZINC ION, D-MALATE, ... (6 entities in total)
• 機能のキーワード: erap1, aminopeptidase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 107126.64

構造登録者

Rowland, P. (登録日: 2019-10-18, 公開日: 2020-03-18, 最終更新日: 2020-04-08)

• 主引用文献: Liddle, J.,Hutchinson, J.P.,Kitchen, S.,Rowland, P.,Neu, M.,Cecconie, T.,Holmes, D.S.,Jones, E.,Korczynska, J.,Koumantou, D.,Lea, J.D.,Nickels, L.,Pemberton, M.,Phillipou, A.,Schneck, J.L.,Sheehan, H.,Tinworth, C.P.,Uings, I.,Wojno-Picon, J.,Young, R.J.,Stratikos, E.; Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.; J.Med.Chem., 63:3348-3358, 2020; PubMed: 32109056; DOI: 10.1021/acs.jmedchem.9b02123

実験手法

X-RAY DIFFRACTION (1.67 Å)