6T6D

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149

Summary for 6T6D

Entry DOI	10.2210/pdb6t6d/pdb
Descriptor	Activin receptor type I, 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, bmp, inhibitor, signalling, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	140817.18
Authors	Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-10-18, release date: 2019-10-30, Last modification date: 2024-01-24)
Primary citation	Ensan, D.,Smil, D.,Zepeda-Velazquez, C.A.,Panagopoulos, D.,Wong, J.F.,Williams, E.P.,Adamson, R.,Bullock, A.N.,Kiyota, T.,Aman, A.,Roberts, O.G.,Edwards, A.M.,O'Meara, J.A.,Isaac, M.B.,Al-Awar, R. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J.Med.Chem., 63:4978-4996, 2020 Cited by PubMed: 32369358 DOI: 10.1021/acs.jmedchem.0c00395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation