6T6D

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149

6T6D の概要

• エントリーDOI: 10.2210/pdb6t6d/pdb
• 分子名称: Activin receptor type I, 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, bmp, inhibitor, signalling, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 140817.18

構造登録者

Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (登録日: 2019-10-18, 公開日: 2019-10-30, 最終更新日: 2024-01-24)

• 主引用文献: Ensan, D.,Smil, D.,Zepeda-Velazquez, C.A.,Panagopoulos, D.,Wong, J.F.,Williams, E.P.,Adamson, R.,Bullock, A.N.,Kiyota, T.,Aman, A.,Roberts, O.G.,Edwards, A.M.,O'Meara, J.A.,Isaac, M.B.,Al-Awar, R.; Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.; J.Med.Chem., 63:4978-4996, 2020; PubMed: 32369358; DOI: 10.1021/acs.jmedchem.0c00395

実験手法

X-RAY DIFFRACTION (2.56 Å)