6T6B

Crystal structure of PPARgamma in complex with compound 16 (MF27)

Summary for 6T6B

Entry DOI	10.2210/pdb6t6b/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[6-[(2,4-dichlorophenyl)sulfonylamino]-1,3-benzothiazol-2-yl]sulfanyl]octanoic acid (3 entities in total)
Functional Keywords	pparg, peroxisome proliferator activated receptor gamma, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32201.30
Authors	Chaikuad, A.,Ni, X.,Hanke, T.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-10-18, release date: 2019-12-11, Last modification date: 2024-01-24)
Primary citation	Hanke, T.,Cheung, S.Y.,Kilu, W.,Heering, J.,Ni, X.,Planz, V.,Schierle, S.,Faudone, G.,Friedrich, M.,Wanior, M.,Werz, O.,Windbergs, M.,Proschak, E.,Schubert-Zsilavecz, M.,Chaikuad, A.,Knapp, S.,Merk, D. A Selective Modulator of Peroxisome Proliferator-Activated Receptor gamma with an Unprecedented Binding Mode. J.Med.Chem., 63:4555-4561, 2020 Cited by PubMed: 32267688 DOI: 10.1021/acs.jmedchem.9b01786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation