6T4J
ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand FM26
Summary for 6T4J
Entry DOI | 10.2210/pdb6t4j/pdb |
Descriptor | Nuclear receptor ROR-gamma, desmosterol, 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid, ... (5 entities in total) |
Functional Keywords | nuclear receptor, allosteric, inverse agonist, inhibitor, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31450.70 |
Authors | de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2019-10-14, release date: 2020-11-18, Last modification date: 2024-01-24) |
Primary citation | de Vries, R.M.J.M.,Meijer, F.A.,Doveston, R.G.,Leijten-van de Gevel, I.A.,Brunsveld, L. Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33536342DOI: 10.1073/pnas.2021287118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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