6T2M

VDR-ZK168281 complex

Summary for 6T2M

Entry DOI	10.2210/pdb6t2m/pdb
Descriptor	Vitamin D3 receptor A, Nuclear receptor coactivator 1, ethyl (~{Z})-3-[1-[(~{E},1~{R},4~{R})-4-[(1~{R},3~{a}~{S},4~{E},7~{a}~{R})-7~{a}-methyl-4-[(2~{Z})-2-[(3~{S},5~{R})-2-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-1-yl]-1-oxidanyl-pent-2-enyl]cyclopropyl]prop-2-enoate, ... (4 entities in total)
Functional Keywords	nuclear receptor, complex, transcription
Biological source	Danio rerio (Zebrafish) More
Total number of polymer chains	2
Total formula weight	36347.45
Authors	Rochel, N.,Belorusova, A.Y. (deposition date: 2019-10-09, release date: 2020-08-26, Last modification date: 2024-01-24)
Primary citation	Belorusova, A.Y.,Chalhoub, S.,Rovito, D.,Rochel, N. Structural Analysis of VDR Complex with ZK168281 Antagonist. J.Med.Chem., 63:9457-9463, 2020 Cited by PubMed: 32787090 DOI: 10.1021/acs.jmedchem.0c00656 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation