6T29

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 18 (CS587)

これはPDB形式変換不可エントリーです。

6T29 の概要

• エントリーDOI: 10.2210/pdb6t29/pdb
• 分子名称: Calcium/calmodulin-dependent protein kinase type 1D, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44113.94

構造登録者

Kraemer, A.,Sorrell, F.,Butterworth, S.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2019-10-08, 公開日: 2019-11-13, 最終更新日: 2024-01-24)

• 主引用文献: Fromont, C.,Atzori, A.,Kaur, D.,Hashmi, L.,Greco, G.,Cabanillas, A.,Nguyen, H.V.,Jones, D.H.,Garzon, M.,Varela, A.,Stevenson, B.,Iacobini, G.P.,Lenoir, M.,Rajesh, S.,Box, C.,Kumar, J.,Grant, P.,Novitskaya, V.,Morgan, J.,Sorrell, F.J.,Redondo, C.,Kramer, A.,Harris, C.J.,Leighton, B.,Vickers, S.P.,Cheetham, S.C.,Kenyon, C.,Grabowska, A.M.,Overduin, M.,Berditchevski, F.,Weston, C.J.,Knapp, S.,Fischer, P.M.,Butterworth, S.; Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesityin VivoMouse Model.; J.Med.Chem., 63:6784-6801, 2020; PubMed: 32433887; DOI: 10.1021/acs.jmedchem.9b01803

実験手法

X-RAY DIFFRACTION (1.484 Å)