6T26

X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine

Summary for 6T26

• Entry DOI: 10.2210/pdb6t26/pdb
• Related: 3E2D
• Descriptor: Alkaline phosphatase, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: enzyme dynamics disordered loop homodimer, hydrolase, non-competative inhibition.
• Biological source: Vibrio sp. G15-21
• Total number of polymer chains: 2
• Total formula weight: 114463.04

Authors

Asgeirsson, B.,Hjorleifsson, J.G.,Markusson, S.,Helland, R. (deposition date: 2019-10-07, release date: 2020-10-21, Last modification date: 2024-01-24)

Primary citation

Asgeirsson, B.,Markusson, S.,Hlynsdottir, S.S.,Helland, R.,Hjorleifsson, J.G.
X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine.
Biochem Biophys Rep, 24:100830-100830, 2020

PubMed Abstract: -nitrophenyl phosphate, the common substrate for alkaline phosphatase (AP), is available as a cyclohexylamine salt. Here, we report that cyclohexylamine is a non-competitive inhibitor of APs.

PubMed: 33102813
DOI: 10.1016/j.bbrep.2020.100830

Experimental method

X-RAY DIFFRACTION (2.265 Å)