6T26

X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine

6T26 の概要

• エントリーDOI: 10.2210/pdb6t26/pdb
• 関連するPDBエントリー: 3E2D
• 分子名称: Alkaline phosphatase, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: enzyme dynamics disordered loop homodimer, hydrolase, non-competative inhibition.
• 由来する生物種: Vibrio sp. G15-21
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114463.04

構造登録者

Asgeirsson, B.,Hjorleifsson, J.G.,Markusson, S.,Helland, R. (登録日: 2019-10-07, 公開日: 2020-10-21, 最終更新日: 2024-01-24)

主引用文献

Asgeirsson, B.,Markusson, S.,Hlynsdottir, S.S.,Helland, R.,Hjorleifsson, J.G.
X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine.
Biochem Biophys Rep, 24:100830-100830, 2020

PubMed Abstract: -nitrophenyl phosphate, the common substrate for alkaline phosphatase (AP), is available as a cyclohexylamine salt. Here, we report that cyclohexylamine is a non-competitive inhibitor of APs.

PubMed: 33102813
DOI: 10.1016/j.bbrep.2020.100830

実験手法

X-RAY DIFFRACTION (2.265 Å)