6T1G

Streptavidin variants harbouring an artificial organocatalyst based cofactor

Summary for 6T1G

• Entry DOI: 10.2210/pdb6t1g/pdb
• Descriptor: Streptavidin, 5-[(3~{a}~{S},4~{S},6~{a}~{R})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]-~{N}-(1-pyridin-4-ylpiperidin-4-yl)pentanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: artificial cofactor, streptavidin, catalyst, biotin-binding protein
• Biological source: Streptomyces avidinii
• Total number of polymer chains: 2
• Total formula weight: 33806.98

Authors

Lechner, H.,Hocker, B. (deposition date: 2019-10-04, release date: 2020-10-14, Last modification date: 2021-05-12)

• Primary citation: Lechner, H.,Emann, V.R.,Breuning, M.,Hocker, B.; An Artificial Cofactor Catalyzing the Baylis-Hillman Reaction with Designed Streptavidin as Protein Host*.; Chembiochem, 22:1573-1577, 2021; PubMed: 33400831; DOI: 10.1002/cbic.202000880

Experimental method

X-RAY DIFFRACTION (1.9 Å)